Detection of Sub-Clinical Lead Toxicity in Monocasters

Lead poisoning has been documented since antiquity but occupational lead intoxication still continues to occur (Rampe] 1989). Now there is a growing consensus that low levels of lead exposure often do not result in the manifestation of toxic symptoms, but may have sub- clinical toxicity on haemopoit ic and renal system (Marks (1985; Hunter 1986; Goyer 1990).

Publication Type

Research Article

Experts

B. D. Kumar, K. Krishnaswamy

Time Frame

1994

Description

Lead poisoning has been documented since antiquity but occupational lead intoxication still continues to occur (Rampe] 1989). Now there is a growing consensus that low levels of lead exposure often do not result in the manifestation of toxic symptoms, but may have sub- clinical toxicity on haemopoit ic and renal system (Marks (1985; Hunter 1986; Goyer 1990). Such toxicities are reported even at blood lead concentrations which were thought to be safe (60-80 ~ag/d]) a decade ago (Who 1986; Staessen eta], 1992). One of the several effects of lead, is inhibition of erythrocyte de] ta-amino] evu] inic acid dehydratase (d-ALAD), rate limiting enzyme of the heme synthesis (Gibsson et a] 1968; Sassa et a] 1973; Marks 1985). Similar effect on d-ALAD has been reported even at the blood lead concentrations of 20-30 ~g/d] which are much below the toxic limits of 60 ~g/d] (WHO 1986; Somashekhariah et al, 1990).

Additional information

Publication Type

Research Article

Experts

B. D. Kumar, K. Krishnaswamy

Time Frame

1994