Therapeutic potential of thiamine in lead toxicity -a clinical study

Occupational exposure to lead is hazardous and hence requires to be prevented and treated. The use of sensitive biochemical markers such as erythrocytic ALAD and renal tubular lysosomal enzyme NAG are gaining importance as early parameters to detect exposure to lead and sub-clinical toxicity.

Publication Type

Research Article

Experts

B. Dinesh Kumar, Kamala Krishnaswamy, Md. Moinuddin Khan

Time Frame

1994

Read More Category:

Description

Occupational exposure to lead is hazardous and hence requires to be prevented and treated. The use of sensitive biochemical markers such as erythrocytic ALAD and renal tubular lysosomal enzyme NAG are gaining importance as early parameters to detect exposure to lead and sub-clinical toxicity. The monocasters, occupationally exposed to lead continuously for 1 O-l 5 Years had significant high blood lead levels (44.1tl.3 ua/dl). imoaired ALAD activitv (227 2 57 nmole/hr/ml)-coupled with increased % stimulation in vitro (239’2 72) and elevated enzymuria as chelator of lead from tissues. Wii the administration of thiamine there was a significant reduction in blood lead levels (33.2* 1.8 pg/dl), and reversion in basal ALAD activity (281 -L 33 nmol/hr/ml) and in vitro % stimulation (154 * 7.0) in a span of 12 months. The results indicate the beneficial effect of thiamine in the treatment of chronic subclinical lead toxicity.

Additional information

Publication Type

Research Article

Experts

B. Dinesh Kumar, Kamala Krishnaswamy, Md. Moinuddin Khan

Time Frame

1994